Blackbird, FEMME, Blaenavon, Flyte, The Big Moon, Pesky, D.I.D, Lisa Mitchell, Max Jury, Flawes, Sivu, and George Cosby are all among the 24 artists taking part.
The release follows the success of last year's album, which also featured Blackbird, along with Slow Club, Rae Morris, Lucy Rose, The Districts, Summer Camp and Billie Marten, in addition to gaining support from BBC6Music, XFM, Radio 1, NME and Stereogum.
An album launch is taking place tomorrow night at Hornsey Town Hall Arts Centre in London, with Lisa Mitchell headlining. Tickets are on sale now.
Daisy Digital are donating proceeds from the show and the compilation to CoppaFeel! breast cancer awareness charity.
You can pre-order the album on Bandcamp ahead of its release on 11 December. Itching to get festive? You can grab the first compilation (featuring Layla, Fyfe, PINS, and more) and the second one (Rae Morris, Lucy Rose, Slow Club, Summer Camp, and more) already.
CoppaFeel is the first breast cancer charity in the UK to create awareness amongst young people, with the aim of instilling a new healthy habit that could one day save their life.
Listen to Blackbird's version of Joni Mitchell's "River" below.